Well I have a 60GB and would try it, but knowing my luck it will blow half the components out the top along with the dust.
I usually get an old (very soft) T-Shirt to wipe my PS3 with every now and then. It gets dusty again in about 30 minutes (literally) so I don't know why I even bother. Even the area under the flap where the card readers are gets dusty. I know it's dust and it gets everywhere but it's still annoying.